top of page

Publications

  • Number of Publications: 40

  • H-index: 20 (source: google scholar)

  • Number of Citations: >2300 (source: google scholar)

  1. Mpekris F. *, Panagi M., Charalambous A., Voutouri C., Stylianopoulos T. *, (2024). Modulating cancer mechanopathology to restore vascular function and enhance immunotherapy, Cell Reports Medicine 101626 [DOI:10.1016/j.xcrm.2024.101626]. * Corresponding authors.

  2. Mpekris F. *, Panagi M., Charalambous A., Voutouri C., Michael C., Papoui A., Stylianopoulos T. *, (2024). A synergistic approach for modulating the tumor microenvironment to enhance nano-immunotherapy in sarcomas, Neoplasia 51: 100990 [DOI:10.1016/j.neo.2024.100990]. * Corresponding authors.

  3. Panagi M., Mpekris F., Voutouri C., Hadjigeorgiou A., Michael C., Stylianou A., Constantinidou A., Martin J.D., Cabral H., Stylianopoulos T., (2024). Reprogramming tumor resident mast cells restores T cell infiltration and sensitizes sarcomas to PD-L1 inhibition, Clinical Cancer Research 30 (11): 2582–2597. [DOI: 10.1158/1078-0432.CCR-24-0246].

  4. Charalambous A., Mpekris F., Panagi M., Voutouri C., Michael C., Gabizon A.A., Stylianopoulos T., (2024). Tumor microenvironment reprogramming improves nanomedicine-based chemo-immunotherapy in sarcomas, Molecular Cancer Therapeutics. [DOI: 10.1158/1535-7163.MCT-23-0772].

  5. Mpekris F., Papaphilippou P.C., Panagi M., Voutouri C., Michael C., Charalambous A., Dinev M.M., Katsioloudi A., Prokopi-Demetriades M., Anayiotos A., Cabral H., Krasia-Christoforou T., Stylianopoulos T., (2023). Pirfenidone-loaded polymeric micelles as an effective mechanotherapeutic to potentiate immunotherapy in mouse breast cancer models, ACS Nano 17, 24: 24654–24667. [DOI:10.1021/acsnano.3c03305].

  6. Mpekris F.*, Panagi M.*, Michael C., Voutouri C., Tsuchiya M., Wagatsuma C., Kinoh H., Osada A., Akinaga S.,  Yoshida S., Martin J.D., Stylianopoulos T., (2023). Translational nanomedicine potentiates immunotherapy in sarcoma by normalizing the microenvironment, J Controlled Release, 353: 956-964, [DOI:10.1016/j.jconrel.2022.12.016]            * Equal contribution. 

  7. Stylianou A., Voutouri C., Mpekris F.,  Stylianopoulos T., (2023). Pancreatic cancer presents distinct nanomechanical properties during progression, Ann Biomed Eng 52 (7): 1602-1615 [DOI: doi.org/10.1007/s10439-023-03168-3].

  8. Theodorou I., Mpekris F., Papagiorgis P., Panagi M., Kalli M., Potamiti L., Kyriacou K., Itskos G., Stylianopoulos T., (2023). Gold Nanobipyramids for Near Infrared Fluorescence-Enhanced Imaging and Treatment of Triple Negative Breast Cancer. Cancers 15, 3693 [DOI: 10.3390/cancers15143693].

  9. Voutouri C., Mpekris F., Panagi M., Michael C., Martin J.D., Averkiou M., Stylianopoulos T., (2023). Ultrasound stiffness and perfusion markers correlate with tumor volume responses to immunotherapy, Acta Biomaterialia 1,167:121-134. [DOI: 10.1016/j.actbio.2023.06.007]

  10. Kalli M., Mpekris F., Charalambous A., Michael C., Stylianou C., Voutouri C., Hadjigeorgiou A.G., Papoui A., Martin J.D., Stylianopoulos T., Mechanical stress induced autophagy impairs the efficacy of oxaliplatin in pancreatic cancer (Under Review).

  11. Martin J.D., Nagaoka K.,  Panagi M.; Hosoi A., Mpekris F., Chen P, Khan T., Martin M., Sun C., Voutouri C.., Louca M., Papageorgis P., Sumiyoshi A., Nitta N., Takeda K., Aoki I., Kataoka K., Stylianopoulos T., Kakimi K., Cabral H., Antiemesis Corticosteroids Potentiate Checkpoint Blockade Efficacy by Normalizing the Immune Microenvironment in Metastatic Murine Breast Cancer (Under Review).

  12. Martin J.D., Mpekris F., Martin M.R, Chauhan V.P., M.E. Walsh M.E., Stuber M.D., McDonald D.M., F. Yuan F., Stylianopoulos T., R.K. Jain R.K., Transvascular transport of molecular and nanoscale medicines in tumors (Under review).

  13. Mpekris F., Voutouri C., Panagi M., Baish J.W, Stylianopoulos T., Jain R.K., (2022). Normalizing the tumor microenvironment with nanomedicine and metronomic therapy: Implications for immunotherapy, J Controlled Release, 345: 190-199. [DOI: 10.1016/j.jconrel.2022.03.008]

  14. Panagi M.*, Mpekris F.*, Chen P.*, Voutouri C., Nakagawa Y., Martin J.D., Hiroi T., Hashimoto H., Philippos D.,  Pierides C., Samuel R., Fukushima S., Georgiou P., Papageorgis P., Papaphillipou P.C., Michael C., Koumas L.,  Costeas P., Ishii G., Kojima M., Kataoka K., Cabral H., Stylianopoulos T., (2022). Polymeric micelles increase tumor microenvironment reprogramming efficiency to potentiate nano-immunotherapy, Nature Communications 13, 7165, [DOI: 10.1038/s41467-022-34744-1]  * Equal contribution.

  15. Stylianou A., Mpekris F., Voutouri C., Papoui A., Constantinidou A., Kitiris E., Kailides M., Stylianopoulos T., (2022). Nanomechanical properties of solid tumors as treatment monitoring biomarkers, Acta Biomaterialia 16:21. [DOI:10.1016/j.actbio.2022.10.021]

  16. Papaphilippou P.Ch., O.A Marinica O.A., Tanasa E., Mpekris F., Stylianopoulos T., Socoliuc V., Krasia-Christoforou T., (2022). Ofloxacin Removal from Aqueous Media by Means of Magnetoactive Electrospun Fibrous Adsorbents. Nanomaterials 12(20), 3648 [DOI:10.3390/nano12203648]     

  17. Mpekris F., Panagi M., Voutouri C., Martin J.D., Samuel R., Takahashi S., Gotohda N., Suzuki T., Papageorgis P., Demetriou P., Pierides C., Koumas L., Costeas P., Kojima M., Ishii G., Constantinidou A., Kataoka K., Cabral H., Stylianopoulos T. (2021). Normalizing the microenvironment overcomes vessel compression and resistance to nano-immunotherapy in breast cancer lung metastasis. Advanced Science 8(3): e2001917 [DOI:10.1002/advs.202001917]

  18. Voutouri C.*, Panagi M.*, Mpekris F.*, Stylianou A., Averkiou M., Martin J.D., Stylianopoulos T. (2021). Endothelin inhibition potentiates cancer immunotherapy revealing mechanical biomarkers predictive of response. Advanced Therapeutics, 2000289, [DOI:10.1002/adtp.202000289] * Equal contribution.

  19. Igarashi K., Cabral H., Hong T., Anraku Y., Mpekris F., Stylianopoulos T., Khan T., Matsumoto A., Kataoka K, Matsumoto Y., Yamasoba T., (2021) Vascular Bursts Act as a Versatile Tumor Vessel Permeation Route for Blood-Borne Particles and Cells, Small 17(42): 2103751 [DOI:10.1002/smll.202103751].           

  20. Mpekris F., Voutouri C., Baish J.W, Duda D.G., Munn L.L., Stylianopoulos T., Jain R.K. (2020). Combining microenvironment normalization strategies to improve cancer immunotherapy. PNAS 117(7):3728-3737 [DOI:10.1073/pnas.1919764117]

  21. Panagi M., Voutouri C., Mpekris F., Papageorgis P., Martin M.R., Martin J.D, Dmetriou P., Pierides C., Polydorou C., Stylianou A., Louca M., Koumas L., Costeas P., Kataoka K., Cabral H., Stylianopoulos T. (2020). TGF-β inhibition combined with nanomedicine normalizes the metastasis microenvironment towards anti-tumor immunity. Theranostics 10(4):1910-1922 [DOI:10.7150/thno.36936]

  22. Martin J.D., Panagi M., Khan T.T., Wang C., Martin M.R., Voutouri C., Toh K., Papageorgis P., Mpekris F., Suzuki T., Wilheim M., Melo V.A., Polydorou C., Quader S., Norimatsu J., Lanning R.M., Kojima M., Stuber M.D., Stylianopoulos T., Cabral H., Kataoka K. (2019). Dexamethasone increases nanocarrier delivery by normalizing the tumor microenvironment. ACS Nano 13(6):6396-6408 [DOI:10.1021/acsnano. 8b07865]  

  23. Zhao Y., Cao J., Jones D., Zhang Y., Nia H.T., Stylianopoulos T., Mpekris F., Datta M., Sun Y., Wu L., Gao X., Jain R.K., Xu L. (2019). Losartan treatment augments chemotherapy efficacy and reduces ascites by normalizing the tumor stroma in ovarian cancer models. PNAS 116(6):2210-2219 [DOI:10.1073/pnas. 1818357116]

  24. Voutouri C., Kirkpatrick N.D., Chung E., Mpekris F., Baish J.W, Munn L.L, Fukumura D., Stylianopoulos T., Jain R.K. (2019). Dynamics of vessel cooption in brain tumors revealed by integrative experimental and mathematical modeling studies. PNAS 116(7):2662-2671 [DOI:10.1073/pnas. 1818322116]

  25. Kalli M., Mpekris F., Wong K.C., Panagi M., Ozturk S., Thiagalingam S., Stylianopoulos T., Papageorgis P. (2019). Activin A signaling regulates IL13Rα2 expression to promote breast cancer metastasis. Front Oncol 9: 32. [DOI: 10.3389/fonc.2019.00032]

  26. Demetriadou C., Pavlou D., Mpekris F., Achilleos C., Stylianopoulos T., Zaravinos A., Papageorgis P., Kirmizis A. (2019). Naa40 contributes to colorectal cancer growth by controlling PRMT5 expression. Cell Death and Disease 10 (3):236. [DOI: 10.1038/s41419-019-1487-3]

  27. Mpekris F., Voutouri C., Papageorgis P., Stylianopoulos T. (2018). Stress alleviation strategy in cancer treatment: Insights from a mathematical model. Z Angew Math Mech., 1-12. [DOI: 10.1002/zamm.21700270]

  28. Mpekris F., Baish J.W., Stylianopoulos T., Jain R.K. (2017). Role of vascular normalization in benefit from metronomic chemotherapy. PNAS, 114(8):1994-1999 [DOI:10.1073/pnas.1700340114]

  29. Mpekris F., Papageorgis P., Polydorou C., Voutouri C., Kalli M., Pirentis A., Stylianopoulos T. (2017) Sonic-Hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo- and nanotherapy, J Controlled Release, 261: 105-112. [DOI: 10.1016/j.jconrel.2017.06.022]              

  30. Papageorgis P.*, Polydorou C.*, Mpekris F.*, Voutouri C., Agathokleous E., Kapnissi-Christodoulou C.P., Stylianopoulos T. (2017) Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo- and nanotherapeutics in a size independent manner. Scientific Reports, 7:46140 [DOI: 10.1038/srep46140] * Equal contribution

  31. Polydorou C.*, Mpekris F.*, Papageorgis P., Voutouri C., Stylianopoulos T. (2017). Pirfenidone normalizes the tumor microenvironment to improve chemotherapy, Oncotarget, 8(15):24506-24517. [DOI:10.18632/oncotarget.15534] *Equal Contribution

  32. Ilia R., Liatsou I., Savva I., Vasile E., Vekas L., Marinica O., Mpekris F., Pashalidis I., Krasia-Christoforou T. (2017). Magnetoresponsive Polymer Networks as Adsorbents for the Removal of U(VI) Ions from Aqueous Media, Eur. Pol. J., 97: 138-146 [DOI:10.1016/j.eurpolymj.2017.10.005]

  33. Achilleos M., Mpekris F., Stylianopoulos T., Krasia-Christoforou T. (2016). Structurally-defined semi-interpenetrating amphiphilic polymer networks with tunable and predictable mechanical response. RSC Advances 6:43278-43283 [DOI: 10.1039/C6RA07376j]

  34. Mpekris F., Angeli S., Pirentis A.P., Stylianopoulos T. (2015), Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation and drug delivery. Biomechanics and Modeling in Mechanobiology 14(6):1391-1402 [DOI: 10.1007/s10237-015-0682-0]

  35. Savva I., Evaggelou E., Papaparaskeva G., Leontiou T., Stylianopoulos T., Mpekris F., Stylianou K., Krasia-Christoforou T. (2015), Alignment of electrospun polymer fibers using a concave collector. RSC Advances 5(126): 104400-104407. [DOI: 10.1039/C5RA20429A]

  36. Papaphilippou P.Ch., Vyrides I., Mpekris F., Stylianopoulos T., Papatryphonos C.A., Theocharis C.R., Krasia-Christoforou T. (2015), Evaluation of novel, cationic electrospun microfibrous membranes as adsorbents in bacteria removal. RSC Advances 5(83): 67617-67629. [DOI: 10.1039/C5RA11406C]

  37. Pirentis A.P., Polydorou C., Papageorgis P., Voutouri C., Mpekris F., T. Stylianopoulos T. (2015). Remodelling of extracellular matrix due to solid stress accumulation during tumour growth. Connective Tissue Research 56(5): 345-354. [DOI: 10.3109/03008207.2015.1047929]

  38. Mpekris F., Achilleos M., Vasile E., Vasile E., Krasia-Christoforou T., Stylianopoulos T. (2015), Mechanical Properties of Structurally-Defined Magnetoactive Polymer (Co)networks. RSC Advances 5:20011-20019 [DOI: 10.1039/C4RA16260A]

  39. Voutouri C.*, Mpekris F.*, Papageorgis P., Odysseos A.D., Stylianopoulos T. (2014) Role of constitutive behavior and tumor-host mechanical interactions in the state of stress and growth of solid tumors. Plos One 9: e104717 [DOI: 10.1371/journal.pone.0104717], * Equal Contribution

  40. Stylianopoulos T., Martin J.D., Snuderl M., Mpekris F., Jain S.R., Jain R.K. (2013) Coevolution of solid stress and interstitial fluid pressure in tumors during progression: implications for vascular collapse. Cancer Res 73:3833-3841 [DOI: 10.1158/0008-5472.CAN-12-4521]

bottom of page